Diastolic blood pressure

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funders: Burroughs Wellcome Fund and 3 more

Humans2

Outcomes

White matter hyperintensity volume

downin humans1

1 study

Diastolic blood pressure decreases white matter hyperintensity volume in humans (-13% (95% CI, -21% to -3%)).
“participants with DBP <80 mm Hg had 13% lower WMHV in the frontal lobe (95% CI, -21% to -3%)”
Humansrelative to DBP 90+ mm Hgfrontal lobe<80 mm Hgn = 1,205
Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study
Stroke8 Jan 2020

Associations

NfL

downin humans1

1 study

Diastolic blood pressure is associated with NfL in humans.
“higher DBP and clinical blood pressure categories were associated with lower levels of select plasma biomarkers of neurodegeneration (NfL and GFAP).”
Humanscognitively normal older adults without hypotension or hypertensive crisisplasma
Contrasting associations of diastolic blood pressure with plasma amyloid, tau, and neurodegeneration biomarkers in the Health and Aging Brain Study-Health Disparities (HABS-HD)
Journal of Alzheimer's disease : JAD13 Mar 2026