Diapause

1. Diapause decreases rate of aging.

   “many diapausing organisms appear to substantially slow or suspend aging”

   Reviewduring diapause/dormancy

   Diapause and aging: Two opposing yet intertwined biological phenomena

   Ageing research reviews·Dec 16, 2025

1. Diapause induces DNA damage response in flies.

   “During dormancy, germline stem cells (GSCs) incur DNA damage, activate p53 and Chk2, and divide less.”

   Model organismsduring dormancyovary

   Enhanced germline stem cell longevity in Drosophila diapause

   Nature communications·Feb 7, 2022

More on DNA damage response

1. Diapause is associated with cellular quiescence in flies.

   “Our data are consistent with a model wherein diapause induces cellular quiescence in the fat body”

   Model organismsfat body

   Multiomic Analysis of Adult Diapause in Drosophila melanogaster Identifies Hallmarks of Cellular Quiescence

   bioRxiv (Cold Spring Harbor Laboratory)·Dec 21, 2022Preprint

1. Diapause is associated with chromatin and 3D genome organization in flies.

   “our observations suggest chromatin is globally reorganized in diapause”

   Model organismsfat body

   Multiomic Analysis of Adult Diapause in Drosophila melanogaster Identifies Hallmarks of Cellular Quiescence

   bioRxiv (Cold Spring Harbor Laboratory)·Dec 21, 2022Preprint

More on Chromatin and 3D genome organization