Danazol
- 1 lab
- Human trial1
Outcomes
3MII oocyte rate
upin humans1
1 study
MII oocyte rate
upin humans1
Danazol increases MII oocyte rate in humans.
“all Danazol-treated patients had a better MII oocyte rate compared to OS performed before the pilot study.”
Human trialovarian stimulation after the trial versus before the pilot study in women with diminished ovarian reserveovaryfemales
Women's health reports (New Rochelle, N.Y.)1 Feb 2023
Antral follicle count
no changein humans1
1 study
Antral follicle count
no changein humans1
Danazol has no effect on antral follicle count in humans.
“Regarding fertility, no differences were found in the antral follicle count.”
Human trialdiminished ovarian reserveovaryfemales
Women's health reports (New Rochelle, N.Y.)1 Feb 2023
Telomere length
no changein humans1
1 study
Telomere length
no changein humans1
Danazol has no effect on telomere length in humans.
“the mean telomere length in blood and the percentage of short and long telomeres were similar throughout the 3 months of treatment with Danazol.”
Human trialdiminished ovarian reserveblood3 monthsfemales
Women's health reports (New Rochelle, N.Y.)1 Feb 2023
Associations
1TERRA foci
mixedin humans1
1 study
TERRA foci
mixedin humans1
Danazol is associated with TERRA foci in humans (Cells with one focus decreased (p = 0.04); cells with 2 to 4 foci increased (p = 0.02)).
“after the first month of Danazol treatment, the number of cells with 2 to 4 TERRA foci increased (p = 0.02).”
Human trialdiminished ovarian reservefemales
Women's health reports (New Rochelle, N.Y.)1 Feb 2023