Daily activity

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funder: Association Nationale de la Recherche et de la Technologie

Humans1
Animals1

Outcomes

Healthy aging

mediatesin humans1

1 study

Daily activity mediates healthy aging in humans.
“Social support influenced healthy aging indirectly through daily activity, and physical function had an indirect effect via daily activity.”
Humanscommunity-dwelling frail older adultsn = 505
Exploring Factors Influencing Healthy Aging in Frail Older Adults: A Multidimensional Model Approach
GSA 2025 abstract31 Dec 2025

Associations

Healthy aging

upin humans1

1 study

Daily activity is associated with healthy aging in humans.
“Resilience, cognitive function, and perceived health had both direct and indirect effects on healthy aging, while daily activity had a direct effect.”
Humanscommunity-dwelling frail older adultsn = 505
Exploring Factors Influencing Healthy Aging in Frail Older Adults: A Multidimensional Model Approach
GSA 2025 abstract31 Dec 2025

Frailty phenotype

downin dogs1

1 study

Daily activity lowers the risk of frailty phenotype in dogs.
“Engaging in daily activity higher than 15 min per day was negatively associated with frailty phenotype”
Animalshigher than 15 min per dayn = 566
Comparison of the frailty phenotype and frailty index for identifying vulnerable companion dogs
Scientific reports24 Dec 2025