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Dactinomycin

Intervention

1 paper2 findings

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Government of Jiangsu Province and 3 more

Outcomes

2

Cellular senescence

upin cells1

1 study

  1. Dactinomycin induces cellular senescence in cells.

    “Exposure to nucleolar stress inducers CX-5461 and actinomycin D (ActD) resulted in senescence-associated β-gal staining (SA-β-gal) activity in cultured β cells.”

    Cellsin cultured beta cells

    Nucleolar stress facilitates islet β cell senescence via hijacking the DNA damage response pathways

    iScience4 Sep 2025

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Cytoplasmic aspartate aminotransferase

downin rats1

1 study

  1. Dactinomycin inhibits cytoplasmic aspartate aminotransferase in rats.

    “The hormone-mediated induction of this isoenzyme is actinomycin D-sensitive.”

    Animalshormone-mediated induction of cytoplasmic AsATlivermales

    Differential effects of hydrocortisone on aspartate aminotransferase isoenzymes of the liver of rats during growth, development, and senescence

    Biochemistry international1 Sep 1987

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