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Cysteine and methionine deprivation

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 6 more
  • Animals1

Outcomes

1

Ferroptosis

upin mouse cells1

1 study

  1. Cysteine and methionine deprivation induces ferroptosis in mouse cells.

    “cysteine and methionine deprivation (CMD) can synergize with the GPX4 inhibitor RSL3 to increase ferroptotic cell death and lipid peroxidation”

    Cellssynergy with RSL3 in murine and human glioma cell lines and ex vivo organotypic slice cultures

    Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

    Nature communicationsMar 2, 2023

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