Cystathionine gamma-lyase gene therapy

1. Cystathionine gamma-lyase gene therapy decreases cellular senescence in human cells.

   “Adenoviral overexpression of CSE in human native aged endothelial cells maintained low p53 activity and re-activated telomerase to revert endothelial cell senescence.”

   Cellsadenoviral CSE overexpressionnative endothelial cell

   A novel role for cystathionine γ lyase in the control of p53: impact on endothelial senescence and metabolic reprograming

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 5, 2022Preprint

2. Cystathionine gamma-lyase gene therapy prevents cellular senescence in mice.

   “the AAV9 mediated re-expression of an active CSE mutant retained p53 in the cytosol, maintained endothelial glucose metabolism and proliferation, and prevented endothelial cell senescence.”

   Animalsendothelial cell CSE lossAAV9-mediated active CSE mutantendothelial cell

   A novel role for cystathionine γ lyase in the control of p53: impact on endothelial senescence and metabolic reprograming

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 5, 2022Preprint

More on Cellular senescence

1. Cystathionine gamma-lyase gene therapy increases telomerase activity in human cells.

   “Adenoviral overexpression of CSE in human native aged endothelial cells maintained low p53 activity and re-activated telomerase to revert endothelial cell senescence.”

   Cellsadenoviral CSE overexpressionnative endothelial cell

   A novel role for cystathionine γ lyase in the control of p53: impact on endothelial senescence and metabolic reprograming

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 5, 2022Preprint

More on Telomerase activity