Cycloastragenol derivatives

1. Cycloastragenol derivatives decrease cell killing (cytotoxicity) in human cells.

   “derivatives exhibited neuroprotective properties by attenuating glutamate-induced excitotoxicity”

   Cellsagainst glutamate-induced excitotoxicity

   Multi-Targeted Effects of Novel Cycloastragenol Derivatives: Enhancing NRF2, Proteostasis, and Telomerase Pathways with p53 Modulation to Delay Replicative Senescence

   bioRxiv (Cold Spring Harbor Laboratory)·Aug 12, 2024Preprint

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1. Cycloastragenol derivatives extend lifespan in human cells.

   “increased NRF2, proteasome, and hTERT protein levels even in senescent cells and extended cellular lifespan”

   Cellsin HEKn

   Multi-Targeted Effects of Novel Cycloastragenol Derivatives: Enhancing NRF2, Proteostasis, and Telomerase Pathways with p53 Modulation to Delay Replicative Senescence

   bioRxiv (Cold Spring Harbor Laboratory)·Aug 12, 2024Preprint

1. Cycloastragenol derivatives improve proteostasis in human cells.

   “derivatives also markedly increased proteasome activity, particularly in the β1 and β5 subunits, thereby preserving proteostasis”

   Cellsin HEKn

   Multi-Targeted Effects of Novel Cycloastragenol Derivatives: Enhancing NRF2, Proteostasis, and Telomerase Pathways with p53 Modulation to Delay Replicative Senescence

   bioRxiv (Cold Spring Harbor Laboratory)·Aug 12, 2024Preprint

More on Proteostasis

1. Cycloastragenol derivatives activate NRF2–KEAP1 antioxidant response in human cells.

   “CA derivatives significantly enhance NRF2 nuclear activity”

   Cellsin HEKn

   Multi-Targeted Effects of Novel Cycloastragenol Derivatives: Enhancing NRF2, Proteostasis, and Telomerase Pathways with p53 Modulation to Delay Replicative Senescence

   bioRxiv (Cold Spring Harbor Laboratory)·Aug 12, 2024Preprint

More on NRF2–KEAP1 antioxidant response

1. Cycloastragenol derivatives decrease cellular senescence in human cells.

   “delay replicative senescence in human primary epidermal keratinocytes (HEKn)”

   Cellsreplicative senescence in HEKn

   Multi-Targeted Effects of Novel Cycloastragenol Derivatives: Enhancing NRF2, Proteostasis, and Telomerase Pathways with p53 Modulation to Delay Replicative Senescence

   bioRxiv (Cold Spring Harbor Laboratory)·Aug 12, 2024Preprint

More on Cellular senescence