Copper overload

1 paper6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Natural Science Foundation of China and 1 more

Model organisms1

Outcomes

6

hif-1

downin worms1

1 study

Copper overload decreases hif-1 in worms.
“downregulated lifespan-related genes aak-2 and hif-1”
Model organismscopper overload
Copper overload induces lifespan shortening through activating mitochondrial respiration in Caenorhabditis elegans
Journal of hazardous materials30 Dec 2025

aak-2

downin worms1

1 study

Copper overload decreases aak-2 in worms.
“downregulated lifespan-related genes aak-2 and hif-1”
Model organismscopper overload
Copper overload induces lifespan shortening through activating mitochondrial respiration in Caenorhabditis elegans
Journal of hazardous materials30 Dec 2025

Reactive oxygen species

downin worms1

1 study

Copper overload decreases reactive oxygen species in worms.
“which decreased ROS levels and downregulated lifespan-related genes aak-2 and hif-1”
Model organismscopper overload
Copper overload induces lifespan shortening through activating mitochondrial respiration in Caenorhabditis elegans
Journal of hazardous materials30 Dec 2025

More on Reactive oxygen species

Oxidative phosphorylation

upin worms1

1 study

Copper overload activates oxidative phosphorylation in worms.
“copper overload shortened nematode lifespan and reduced infection resistance by activating mitochondrial respiration”
Model organismscopper overload
Copper overload induces lifespan shortening through activating mitochondrial respiration in Caenorhabditis elegans
Journal of hazardous materials30 Dec 2025

More on Oxidative phosphorylation

Infection resistance

downin worms1

1 study

Copper overload impairs infection resistance in worms.
“reduced infection resistance by activating mitochondrial respiration”
Model organismscopper overload
Copper overload induces lifespan shortening through activating mitochondrial respiration in Caenorhabditis elegans
Journal of hazardous materials30 Dec 2025

Lifespan

downin worms1

1 study

Copper overload shortens lifespan in worms.
“copper overload shortened nematode lifespan and reduced infection resistance by activating mitochondrial respiration”
Model organismscopper overload
Copper overload induces lifespan shortening through activating mitochondrial respiration in Caenorhabditis elegans
Journal of hazardous materials30 Dec 2025

Latest

1 in 12 months

Journal of Hazardous Materials3 Jan

Copper overload induces lifespan shortening through activating mitochondrial respiration in Caenorhabditis elegans

Experiments in wormsOxidative phosphorylation