Constant light
5 papers10 findings
- 1 lab in 1 country
- Funder: Russian Foundation for Basic Research
- Animals5
Outcomes
6Lifespan
downin rats2downin mice1
3 studies
Lifespan
downin rats2downin mice1
Constant light shortens lifespan in mice (p = 0.00351).
“The mice from the LL groups survived less than those from the LD group (χ ( 2) = 8.5; p = 0.00351, log-rank test).”
Animalsuntil to natural deathfemalesn = 46
Cell cycle (Georgetown, Tex.)6 May 2013
Constant light shortens lifespan in rats.
“exposure to NL and LL regimens accelerated age-related switch-off of the estrous function (in females), induced development of metabolic syndrome and spontaneous tumorigenesis, and shortened life span both in male and females rats”
Animalscompared to standard 12:12 light/dark regimen
Light-at-night-induced circadian disruption, cancer and aging
Current aging science1 Dec 2012
Constant light shortens lifespan in rats.
“shortened life span both in male and females rats as compared to the standard LD regimen”
Animalscompared to the standard LD regimen
Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats
Aging2 Oct 2009
Uterine neoplasms
upin mice1
1 study
Uterine neoplasms
upin mice1
Constant light increases uterine neoplasms in mice.
“followed by significant acceleration of the development of the spontaneous uterine tumors in female 129/Sv mice.”
Animalsuntil to natural deathfemalesn = 46
Cell cycle (Georgetown, Tex.)6 May 2013
Colon cancer
upin rats1
1 study
Colon cancer
upin rats1
Constant light increases colon cancer in rats.
“The exposure to the LL regimen accelerated colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in rats”
Animals1,2-dimethylhydrazine-treated rats
Light-at-night-induced circadian disruption, cancer and aging
Current aging science1 Dec 2012
Tumor development
upin mice1
1 study
Tumor development
upin mice1
Constant light increases tumor development in mice.
“Exposure to constant illumination was followed by accelerated aging and enhanced spontaneous tumorigenesis in female CBA and transgenic HER-2/neu mice.”
Animalstransgenic HER-2/neu mice and female CBA micefemales
Light-at-night-induced circadian disruption, cancer and aging
Current aging science1 Dec 2012
Metabolic syndrome
upin rats1
1 study
Metabolic syndrome
upin rats1
Constant light increases metabolic syndrome in rats.
“exposure to NL and LL regimens accelerated development of metabolic syndrome and spontaneous tumorigenesis”
Animalscompared to the standard LD regimen
Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats
Aging2 Oct 2009
Spontaneous tumorigenesis
upin rats1
1 study
Spontaneous tumorigenesis
upin rats1
Constant light increases spontaneous tumorigenesis in rats.
“exposure to NL and LL regimens accelerated development of metabolic syndrome and spontaneous tumorigenesis”
Animalscompared to the standard LD regimen
Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats
Aging2 Oct 2009
Associations
2Mortality
upin mice1
1 study
Mortality
upin mice1
Constant light raises the risk of mortality in mice (p = 0.0041).
“constant light regimen increased the relative risk of death in female mice compared with the control (LD) group (p = 0.0041).”
Animalsuntil to natural deathfemalesn = 46
Cell cycle (Georgetown, Tex.)6 May 2013
Tumor
upin rats1
1 study
Tumor
upin rats1
Constant light raises the risk of tumor in rats.
“While delaying tumors in males, constant light accelerated tumors in females.”
Animalsfemales
Aging20 Mar 2010