Community health worker-led interventions

2 papers6 findings

Community health worker-led interventions lower systolic blood pressure in a human trial, with independent replication. The trial reports lower diastolic pressure and unchanged LDL-C; reviews describe lower body mass index but no diastolic change. The Indian Council of Medical Research and Ministry of Health and Family Welfare each fund three of six findings.

Findings from 2 papers since August 2026

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries
1 finding against

Funders: Indian Council of Medical Research and 1 more

Outcomes

Diastolic blood pressure

downin humans1no changein humans1

2 studies

Community health worker-led interventions decrease diastolic blood pressure in humans (WMD = -2.22 mmHg).
“diastolic blood pressure (WMD = -2.22 mmHg; 95% CI: -3.50 to -0.95; I2 = 98.6%)”
Human trial
Effects of community health worker-led interventions on cardiometabolic outcomes in vulnerable populations: A systematic review and meta-analysis
PLOS global public health26 Aug 2026
Community health worker-led interventions have no effect on diastolic blood pressure in humans.
“No significant change was observed in diastolic blood pressure, fasting blood glucose, glycated haemoglobin, and lipid profiles.”
Reviewadults with hypertension, diabetes, stroke, and overweight
Community health worker-led interventions for cardio-metabolic diseases in India: Evidence from a systematic review and meta-analysis
The Indian journal of medical research1 Aug 2026