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Collagen hydrolysate

Intervention

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • Funders: Kyungpook National University and 3 more
  • Human trial1
  • Animals1

Outcomes

3

Ajuba expression

upin mice1

1 study

  1. Collagen hydrolysate increases Ajuba expression in mice.

    “Dietary supplementation restored Ajuba expression across all intervention groups, with the strongest effect observed in the high-molecular-weight collagen group.”

    Animalshigh- and low-molecular-weight hydrolysatesgastrocnemius muscle

    Ajuba as a Potential Nutrition-Responsive Biomarker for the Prevention of Age-Related Sarcopenia

    International journal of molecular sciences14 Aug 2025

More on Ajuba expression

Muscle strength

no changein humans1

1 study

  1. Collagen hydrolysate has no effect on muscle strength in humans (p = 0.247).

    “Evaluation of isometric strength (p = 0.247), insulin-like growth factor 1 (p = 0.705) and the production of reactive oxygen species (pt1 = 0.229; pt2 = 0.741) revealed no significant interaction effect”

    Human trial8 weeksmales

    Effects of Blood Flow Restriction Training with Protein Supplementation on Muscle Mass And Strength in Older Men

    Journal of sports science & medicine1 Aug 2019

IGF-1

no changein humans1

1 study

  1. Collagen hydrolysate has no effect on IGF-1 in humans (p = 0.705).

    “Evaluation of isometric strength (p = 0.247), insulin-like growth factor 1 (p = 0.705) and the production of reactive oxygen species (pt1 = 0.229; pt2 = 0.741) revealed no significant interaction effect”

    Human trial8 weeksmales

    Effects of Blood Flow Restriction Training with Protein Supplementation on Muscle Mass And Strength in Older Men

    Journal of sports science & medicine1 Aug 2019

More on IGF-1

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