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CIRCPVT1-EXO

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Cells1

Outcomes

4

NF-κB signalling

downin human cells1

1 study

  1. CIRCPVT1-EXO inhibits NF-κB signalling in human cells.

    “circPVT1-exo inhibited the NF-κB pathway and increased SIRT1 expression in L-TSPCs.”

    Cellsin aged TSPCs at late passages

    Young TSPC-Derived Exosomal circPVT1 Ameliorates Aging-Impaired Cell Function via SIRT1/NF-κB

    Tissue engineering. Part C, MethodsJan 1, 2024

More on NF-κB signalling

SIRT1

upin human cells1

1 study

  1. CIRCPVT1-EXO increases SIRT1 in human cells.

    “circPVT1-exo inhibited the NF-κB pathway and increased SIRT1 expression in L-TSPCs.”

    Cellsin aged TSPCs at late passages

    Young TSPC-Derived Exosomal circPVT1 Ameliorates Aging-Impaired Cell Function via SIRT1/NF-κB

    Tissue engineering. Part C, MethodsJan 1, 2024

More on SIRT1

Cell proliferation

upin human cells1

1 study

  1. CIRCPVT1-EXO improves cell proliferation in human cells.

    “enhancing self-renewal and proliferation abilities”

    Cellsin aged TSPCs at late passages

    Young TSPC-Derived Exosomal circPVT1 Ameliorates Aging-Impaired Cell Function via SIRT1/NF-κB

    Tissue engineering. Part C, MethodsJan 1, 2024

Cellular senescence

downin human cells1

1 study

  1. CIRCPVT1-EXO inhibits cellular senescence in human cells.

    “These exosomes attenuated the phenotypes of aged TSPCs at late passages (L-TSPCs) by enhancing self-renewal and proliferation abilities, suppressing cell senescence”

    Cellsin aged TSPCs at late passages

    Young TSPC-Derived Exosomal circPVT1 Ameliorates Aging-Impaired Cell Function via SIRT1/NF-κB

    Tissue engineering. Part C, MethodsJan 1, 2024

More on Cellular senescence

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