Circadian reinforcement protocol
Circadian reinforcement protocol has been studied in 1 paper since 2026: 1 trial in people; 1 in the past year. The newest paper, Mar 16, 2026: “Restoring circadian homeostasis is associated with immune-metabolic recovery and medium-term oncologic outcomes after rectal cancer surgery: a prospective randomized trial”.
1 paper studies it3 findingsUpdated
“Circadian reinforcement reduced IL-6 AUC0-7d (362 ± 145 vs 518 ± 183 pg·day/mL; p < 0.001)”
None of its findings points the other way.
- 1 lab in 1 country
- Human trial1
Studies in people
1 study gave circadian reinforcement protocol to people and measured what changed.
down: Decreases IL-6362 ± 145 vs 518 ± 183 pg·day/mL, p < 0.001
down: Decreases prognostic inflammatory and nutritional indexΔPINI -16.9 ± 10.3% vs -30.8 ± 11.4%, p < 0.001
up: Improves disease-free survivalHR 0.56 [0.35-0.89], p = 0.014
Randomized trial240 people3-year
After rectal cancer surgery
Surgical endoscopy, Mar 16, 2026
What did studies of Circadian reinforcement protocol find?
3Studies of Circadian reinforcement protocol measured 3 outcomes; the most studied are disease-free survival (1 study), prognostic inflammatory and nutritional index (1) and IL-6 (1).
Disease-free survival
upin humans1HR 0.56
1 study
Disease-free survival
upin humans1HR 0.56
Circadian reinforcement protocol improves disease-free survival in humans (HR 0.56 [0.35-0.89], p = 0.014).
“intervention was associated with improved 3-year disease-free survival (HR 0.56 [0.35-0.89]; p = 0.014)”
Human trialafter rectal cancer surgery3-yearn = 240
Surgical endoscopy
Prognostic inflammatory and nutritional index
downin humans1
1 study
Prognostic inflammatory and nutritional index
downin humans1
Circadian reinforcement protocol decreases prognostic inflammatory and nutritional index in humans (ΔPINI -16.9 ± 10.3% vs -30.8 ± 11.4%, p < 0.001).
“attenuated inflammatory-nutritional deterioration (ΔPINI -16.9 ± 10.3% vs -30.8 ± 11.4%; p < 0.001)”
Human trialafter rectal cancer surgeryn = 240
Surgical endoscopy
IL-6
downin humans1
1 study
IL-6
downin humans1
Circadian reinforcement protocol decreases IL-6 in humans (362 ± 145 vs 518 ± 183 pg·day/mL, p < 0.001).
“Circadian reinforcement reduced IL-6 AUC0-7d (362 ± 145 vs 518 ± 183 pg·day/mL; p < 0.001)”
Human trialafter rectal cancer surgeryn = 240
Surgical endoscopy