Prognostic inflammatory and nutritional index

1. Circadian reinforcement protocol decreases prognostic inflammatory and nutritional index in humans (ΔPINI -16.9 ± 10.3% vs -30.8 ± 11.4%, p < 0.001).

   “attenuated inflammatory-nutritional deterioration (ΔPINI -16.9 ± 10.3% vs -30.8 ± 11.4%; p < 0.001)”

   Human trialafter rectal cancer surgeryn = 240

   Restoring circadian homeostasis is associated with immune-metabolic recovery and medium-term oncologic outcomes after rectal cancer surgery: a prospective randomized trial

   Surgical endoscopy·Mar 16, 2026

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