Chronic mild stress
3 papers6 findings
- 3 independent labs in 4 countries
- Funders: Ministry of Science and ICT, South Korea and 4 more
- Animals3
Outcomes
6Anxiety-like and depressive-like behavior
upin mice1
1 study
Anxiety-like and depressive-like behavior
upin mice1
Chronic mild stress increases anxiety-like and depressive-like behavior in mice.
“enhanced anxiety-like and depressive-like behavior in aged female, but not male, mice”
Animalsinto late-adulthood15 monthsfemales
Frontiers in aging neuroscienceJan 15, 2025
Hyperactivity
upin mice1
1 study
Hyperactivity
upin mice1
Chronic mild stress increases hyperactivity in mice.
“Stress exposure into late-adulthood increased hyperactivity in both sexes”
Animalsinto late-adulthood15 months
Frontiers in aging neuroscienceJan 15, 2025
Synaptic density per neuron
downin rats1
1 study
Synaptic density per neuron
downin rats1
Chronic mild stress decreases synaptic density per neuron in rats.
“Additionally, the synaptic density per neuron showed a further reduction in the stress aged group.”
Animalsearly adulthood stress and agingdentate gyrus6 weeks stress, tested 20 months later
Frontiers in molecular neuroscienceApr 4, 2024
Long-term potentiation
downin rats1
1 study
Long-term potentiation
downin rats1
Chronic mild stress decreases long-term potentiation in rats.
“Both stress and aging reduced LTP.”
Animalschronic mild stressdentate gyrus6 weeks
Frontiers in molecular neuroscienceApr 4, 2024
Cognitive function
downin rats1
1 study
Cognitive function
downin rats1
Chronic mild stress impairs cognitive function in rats.
“stress and aging impaired different types of memory tasks to varying degrees.”
Animalschronic mild stress6 weeks
Frontiers in molecular neuroscienceApr 4, 2024
Lifespan
no changein mice1
1 study
Lifespan
no changein mice1
Chronic mild stress has no effect on lifespan in mice.
“lifelong exposure of Sub mice to chronic mild stress did not further reduce their lifespan”
Animalsin Sub micelifelong
AgingNov 9, 2019