Chlorate

  • 1 lab in 1 country
  • Funders: Ministry of Education and 1 more
  • Cells1

Outcomes

4

Physical function

downin zebrafish1

1 study
  1. Chlorate impairs physical function in zebrafish.

    Animalschronic low-dose

    Chronic exposure to chlorate at regulatory safety limits induces p21/p16-mediated neuronal senescence and Parkinsonian-like decline

    Environmental pollution (Barking, Essex : 1987)7 Aug 2026

Phosphorylated alpha-synuclein

upin human cells1

1 study
  1. Chlorate increases phosphorylated alpha-synuclein in human cells.

    Cellsat concentrations overlapping with WHO and EPA guidelines

    Chronic exposure to chlorate at regulatory safety limits induces p21/p16-mediated neuronal senescence and Parkinsonian-like decline

    Environmental pollution (Barking, Essex : 1987)7 Aug 2026

More on Phosphorylated alpha-synuclein

NRF2–KEAP1 antioxidant response

upin human cells1

1 study
  1. Chlorate activates NRF2–KEAP1 antioxidant response in human cells.

    Cellsat concentrations overlapping with WHO and EPA guidelines

    Chronic exposure to chlorate at regulatory safety limits induces p21/p16-mediated neuronal senescence and Parkinsonian-like decline

    Environmental pollution (Barking, Essex : 1987)7 Aug 2026

More on NRF2–KEAP1 antioxidant response

Cellular senescence

upin human cells1

1 study
  1. Chlorate induces cellular senescence in human cells.

    Cellsat concentrations overlapping with WHO and EPA guidelines

    Chronic exposure to chlorate at regulatory safety limits induces p21/p16-mediated neuronal senescence and Parkinsonian-like decline

    Environmental pollution (Barking, Essex : 1987)7 Aug 2026

More on Cellular senescence

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