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CCL5

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Institute for Information Industry, Ministry of Science and Technology, Taiwan and 4 more
  • Humans1

Outcomes

2

Angiogenesis

upin mice1

1 study

  1. CCL5 increases angiogenesis in mice.

    “In a mouse hind limb ischemia model, CCL5 improved the angiogenic activity of senescent EPCs.”

    Animalshind limb ischemia model with senescent endothelial progenitor cellshind limb

    Senescence induces miR-409 to down-regulate CCL5 and impairs angiogenesis in endothelial progenitor cells

    Journal of cellular and molecular medicine1 Jun 2024

More on Angiogenesis

Endothelial progenitor cell proliferation

upin human cells1

1 study

  1. CCL5 increases endothelial progenitor cell proliferation in human cells.

    “CCL5 enhanced EPC proliferation via the CCR5/AKT/P70S6K axis and increased vascular endothelial growth factor (VEGF) secretion.”

    Cellsendothelial progenitor cell

    Senescence induces miR-409 to down-regulate CCL5 and impairs angiogenesis in endothelial progenitor cells

    Journal of cellular and molecular medicine1 Jun 2024

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