Cardiosphere-derived cell-derived extracellular vesicles

Intervention

1 paper3 findings

  • 1 lab in 1 country
  • Funders: Cedars-Sinai Medical Center and 3 more
  • Animals1

Outcomes

3

Cellular senescence

downin human cells1

1 study
  1. Cardiosphere-derived cell-derived extracellular vesicles decrease cellular senescence in human cells.

    “EVs secreted by young CDCs exert broad-ranging anti-aging effects in aged rodents and in cellular models of human senescence.”

    Cellsin aged human CSPCs and progeric fibroblasts

    Rejuvenating effects of young extracellular vesicles in aged rats and in cellular models of human senescence

    Scientific reports28 Jul 2023

More on Cellular senescence

Heart function

upin rats1

1 study
  1. Cardiosphere-derived cell-derived extracellular vesicles improve heart function in rats.

    “Treatment with young CDC-EVs induce structural and functional improvements in the heart, lungs, skeletal muscle, and kidneys of old rats”

    Animals4-months

    Rejuvenating effects of young extracellular vesicles in aged rats and in cellular models of human senescence

    Scientific reports28 Jul 2023

Lifespan

upin rats1

1 study
  1. Cardiosphere-derived cell-derived extracellular vesicles extend lifespan in rats.

    “Lifespan was prolonged.”

    Animals4-months

    Rejuvenating effects of young extracellular vesicles in aged rats and in cellular models of human senescence

    Scientific reports28 Jul 2023

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