Cardiac xenotransplantation

2 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Humans1

Outcomes

5

End diastolic diameter

downin humans1

1 study

Cardiac xenotransplantation decreases end diastolic diameter in humans (-40.2% (CI 20.3-64.1%)).
“From post-operative day (POD) 1 of xenotransplant to end-of-life, RVWT increased 80.9% (CI 95.6-118.5%) while EDD decreased 40.2% (CI 20.3-64.1%).”
Human trialin cardiac xenotransplant recipientsheartn = 2
Clinical Correlations with Serial Echocardiography and Global Longitudinal Strain in the First and Second Genetically Modified Porcine to Human Cardiac Xenotransplantation
AHA Scientific Sessions 2025 abstract3 Nov 2025

More on End diastolic diameter

Right ventricular wall thickness

upin humans1

1 study

Cardiac xenotransplantation increases right ventricular wall thickness in humans (80.9% (CI 95.6-118.5%)).
“From post-operative day (POD) 1 of xenotransplant to end-of-life, RVWT increased 80.9% (CI 95.6-118.5%) while EDD decreased 40.2% (CI 20.3-64.1%).”
Human trialin cardiac xenotransplant recipientsheartn = 2
Clinical Correlations with Serial Echocardiography and Global Longitudinal Strain in the First and Second Genetically Modified Porcine to Human Cardiac Xenotransplantation
AHA Scientific Sessions 2025 abstract3 Nov 2025

More on Right ventricular wall thickness

Heart rate

no changein humans1

1 study

Cardiac xenotransplantation has no effect on heart rate in humans (difference of 1.9±3.0, P=0.13).
“The average heart rate (HR) was similar between the 1 st and 2 nd xenotransplant with a HR difference of 1.9±3.0 (75.0±10.0bpm vs 73.1±16.7bpm, P=0.13)”
Human trial1st vs 2nd xenotransplant recipientheartn = 2
Comparison of baseline EKG parameters between the first and second Heart xenotransplant
AHA Scientific Sessions 2025 abstract3 Nov 2025

More on Heart rate

QT interval

upin humans1

1 study

Cardiac xenotransplantation increases QT interval in humans (difference of 132.1±9.7, P<0.001).
“Similarly, the QT interval (ventricular repolarization) was significantly longer in the 1 st xenotransplant compared to the 2 nd, with a difference of 132.1±9.7 (509.0±51.0ms vs 376.9±42.4ms, P<0.001).”
Human trial1st vs 2nd xenotransplant recipientheartn = 2
Comparison of baseline EKG parameters between the first and second Heart xenotransplant
AHA Scientific Sessions 2025 abstract3 Nov 2025

More on QT interval

PR interval

upin humans1

1 study

Cardiac xenotransplantation increases PR interval in humans (difference of 55.2±6.2ms, P<0.001).
“The average PR interval was significantly longer in the 1 st xenotransplant compared to the 2 nd, with a difference of 55.2±6.2ms (212.0±20.0ms vs 156.8±32.5ms, P<0.001).”
Human trial1st vs 2nd xenotransplant recipientheartn = 2
Comparison of baseline EKG parameters between the first and second Heart xenotransplant
AHA Scientific Sessions 2025 abstract3 Nov 2025

More on PR interval

Latest

2 in 12 months

AHA Scientific Sessions 2025 Abstract3 Nov

Comparison of baseline EKG parameters between the first and second Heart xenotransplant

Case series of 2 peopleInterventions

AHA Scientific Sessions 2025 Abstract3 Nov

Clinical Correlations with Serial Echocardiography and Global Longitudinal Strain in the First and Second Genetically Modified Porcine to Human Cardiac Xenotransplantation

Case seriesGlobal longitudinal strain