AgingResearch.NewsJoin free

BX795

Intervention

1 paper studies it1 more mentions it3 findings

PubChemChEBI

Across all fields, 1 paper: none in people yet, 1 in animals

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 2 more
  • Animals1

Outcomes

3

cGAS–STING signaling

downin cells1

1 study

  1. BX795 inhibits cGAS–STING signaling in cells.

    “BX795 inhibited the IL-1β-induced activation of the cGAS-STING and TLR3-TRIF signaling pathways in chondrocytes.”

    CellsIL-1β-induced chondrocytes

    TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes

    Journal of orthopaedic translation

More on cGAS–STING signaling

Cellular senescence

downin mice1

1 study

  1. BX795 decreases cellular senescence in mice.

    “BX795 also counteracted the suppression of anabolic processes and the augmentation of catabolic activity, inflammation, and senescence observed in the OA mice.”

    Animalsin OA miceintra-articular injection

    TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes

    Journal of orthopaedic translation

More on Cellular senescence

Osteoarthritis

downin mice1

1 study

  1. BX795 decreases osteoarthritis in mice.

    “intra-articular injection of BX795 ameliorated cartilage degeneration and alleviated OA-associated pain.”

    Animalsin OA miceintra-articular injection

    TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes

    Journal of orthopaedic translation

More on Osteoarthritis

Latest

Related