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Branched-chain fatty acids

Intervention

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Model organisms2

Outcomes

4

AMPK signalling

downin worms1

1 study

  1. Branched-chain fatty acids inhibit AMPK signalling in worms.

    “downregulates argk-1/creatine kinase to inhibit the AMPK pathway”

    Model organisms

    Branched chain fatty acid-rich diet promotes lipid droplet enlargement and impacts organismal health in Caenorhabditis elegans

    bioRxiv (Cold Spring Harbor Laboratory)Jan 20, 2025Preprint

More on AMPK signalling

Brood size

downin worms1

1 study

  1. Branched-chain fatty acids decrease brood size in worms.

    “delays development, reduces brood size”

    Model organisms

    Branched chain fatty acid-rich diet promotes lipid droplet enlargement and impacts organismal health in Caenorhabditis elegans

    bioRxiv (Cold Spring Harbor Laboratory)Jan 20, 2025Preprint

Lipid droplets

upin worms1

1 study

  1. Branched-chain fatty acids increase lipid droplets in worms.

    “causes the formation of supersized LDs”

    Model organisms

    Branched chain fatty acid-rich diet promotes lipid droplet enlargement and impacts organismal health in Caenorhabditis elegans

    bioRxiv (Cold Spring Harbor Laboratory)Jan 20, 2025Preprint

Lifespan

downin worms1

1 study

  1. Branched-chain fatty acids shorten lifespan in worms.

    “reduces brood size, and shortens lifespan of C. elegans”

    Model organisms

    Branched chain fatty acid-rich diet promotes lipid droplet enlargement and impacts organismal health in Caenorhabditis elegans

    bioRxiv (Cold Spring Harbor Laboratory)Jan 20, 2025Preprint

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