BQ788
- 1 lab in 1 country
- Funders: Health and Medical Research Fund and 2 more
- Animals1
Outcomes
2Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
BQ788 decreases cellular senescence in mice.
“both genetic knockout of ETBR in Prx1+ SSCs and pharmacological inhibition with BQ788 mitigated oxidative stress, reduced cellular senescence, and preserved bone mass in OVX and aged mice.”
Animalsin aged and OVX mice
Journal of orthopaedic translation18 Feb 2026
Bone mass
upin mice1
1 study
Bone mass
upin mice1
BQ788 improves bone mass in mice.
“both genetic knockout of ETBR in Prx1+ SSCs and pharmacological inhibition with BQ788 mitigated oxidative stress, reduced cellular senescence, and preserved bone mass in OVX and aged mice.”
Animalsin aged and OVX mice
Journal of orthopaedic translation18 Feb 2026
Latest
1 in 12 monthsJournal of Orthopaedic Translation
Endothelin-1/endothelin B receptor signalling mediates Prx1⁺ skeletal stem cells senescence: A driver of osteoporotic bone loss
Experiments in micePI3K–AKT signalling