BQ788

  • 1 lab in 1 country
  • Funders: Health and Medical Research Fund and 2 more
  • Animals1

Outcomes

2

Cellular senescence

downin mice1

1 study
  1. BQ788 decreases cellular senescence in mice.

    “both genetic knockout of ETBR in Prx1+ SSCs and pharmacological inhibition with BQ788 mitigated oxidative stress, reduced cellular senescence, and preserved bone mass in OVX and aged mice.”

    Animalsin aged and OVX mice

    Endothelin-1/endothelin B receptor signalling mediates Prx1⁺ skeletal stem cells senescence: A driver of osteoporotic bone loss

    Journal of orthopaedic translation18 Feb 2026

More on Cellular senescence

Bone mass

upin mice1

1 study
  1. BQ788 improves bone mass in mice.

    “both genetic knockout of ETBR in Prx1+ SSCs and pharmacological inhibition with BQ788 mitigated oxidative stress, reduced cellular senescence, and preserved bone mass in OVX and aged mice.”

    Animalsin aged and OVX mice

    Endothelin-1/endothelin B receptor signalling mediates Prx1⁺ skeletal stem cells senescence: A driver of osteoporotic bone loss

    Journal of orthopaedic translation18 Feb 2026

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