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Bio-block

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab
  • Cells1

Outcomes

4

Extracellular vesicles

upin human cells1+44%

1 study

  1. Bio-block increases extracellular vesicles in human cells (~44%).

    “EV production increased ~44% in Bio-Blocks, while other systems declined 30-70%”

    Cellsadipose tissuefour weeks

    Comparison of 3D culture systems on mesenchymal stem cell longevity, regenerative potential, and secretome production

    Regenerative medicine12 Oct 2025

More on Extracellular vesicles

Apoptosis

downin human cells1

1 study

  1. Bio-block decreases apoptosis in human cells (decreased 2-3-fold).

    “senescence reduced 30-37% and apoptosis decreased 2-3-fold”

    Cellsadipose tissuefour weeks

    Comparison of 3D culture systems on mesenchymal stem cell longevity, regenerative potential, and secretome production

    Regenerative medicine12 Oct 2025

More on Apoptosis

Cellular senescence

downin human cells1

1 study

  1. Bio-block decreases cellular senescence in human cells (reduced 30-37%).

    “senescence reduced 30-37% and apoptosis decreased 2-3-fold”

    Cellsadipose tissuefour weeks

    Comparison of 3D culture systems on mesenchymal stem cell longevity, regenerative potential, and secretome production

    Regenerative medicine12 Oct 2025

More on Cellular senescence

Proliferation

upin human cells1

1 study

  1. Bio-block increases proliferation in human cells (~2-fold).

    “Bio-Block ASCs exhibited ~2-fold higher proliferation than spheroid and Matrigel groups”

    Cellsadipose tissuefour weeks

    Comparison of 3D culture systems on mesenchymal stem cell longevity, regenerative potential, and secretome production

    Regenerative medicine12 Oct 2025

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