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Bacterial infection

Intervention

1 paper studies it2 findings

Across all fields, 1 paper: none in people yet, 1 review

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 1 country
  • Funders: National Heart, Lung, and Blood Institute and others

Outcomes

1

Hematopoietic stem cell function

downin mice1

1 study

  1. Bacterial infection impairs hematopoietic stem cell function in mice.

    “we observed an irreversible depletion of functional HSCs following challenge with inflammation or bacterial infection”

    Animalsup to 1 year afterward

    Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging

    Cell stem cell

Associations

1

Intestinal motility

mixedin flies1

1 study

  1. Bacterial infection is associated with intestinal motility in flies.

    “fasting and bacterial infections cause specific changes in the intestinal motility profiles in vivo”

    Model organismsin Drosophila midgut in vivo

    Identification of superstalsis, a motility program distinct from peristalsis in the Drosophila midgut

    Cell reports

Funding

1 grant since 2018

National Heart, Lung, and Blood InstituteUS$803k

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