AZD-1208

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab

Animals1

Outcomes

Cellular senescence

downin mice1downin mouse cells1

1 study

AZD-1208 inhibits cellular senescence in mouse cells.
“Hypoxic conditions significantly enhanced PIM1 expression and senescence markers in fibroblasts, effects that were effectively reversed by PIM1 inhibition.”
Cellshypoxia-treated fibroblasts
PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence
PloS one12 Nov 2025
AZD-1208 decreases cellular senescence in mice.
“Treatment with AZD-1208 led to significant improvements in bladder function and a reduction in senescence burden in vivo.”
Animalsin mouse model of SUI
PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence
PloS one12 Nov 2025

Latest

1 in 12 months

PLOS One12 Nov

PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence

Experiments in miceHypoxia and HIF signalling

Paper

AZD-1208

Outcomes

Latest

PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence

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