Anti-sense oligonucleotide

1. Anti-sense oligonucleotide improves chromatin and 3D genome organisation in silico.

   “demonstrating that ASO partially restores chromatin structure in diseased cells. They additionally quantify the more pronounced effects in HGPS compared to WRN.”

   In silicoin diseased cells (HGPS and WRN)

   Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

   bioRxiv (Cold Spring Harbor Laboratory)·18 May 2025Preprint

More on Chromatin and 3D genome organisation