Anti-papp-a antibody

1. Anti-papp-a antibody decreases mesenchymal stromal cell in mice.

   “Mice treated with anti-PAPP-A had reduced IGF signaling in MSCs and dramatically decreased MSC number.”

   Animalsbone marrow

   Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells

   Aging cell·9 Feb 2021

More on Mesenchymal stromal cell

1. Anti-papp-a antibody decreases bone in mice.

   “where we found reduced bone, marrow adiposity, and myelopoiesis.”

   Animalsbone marrow

   Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells

   Aging cell·9 Feb 2021

1. Anti-papp-a antibody decreases extracellular matrix remodelling in mice.

   “anti-PAPP-A reduced IGF signaling and extracellular matrix (ECM) gene expression system wide.”

   Animals

   Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells

   Aging cell·9 Feb 2021

More on Extracellular matrix remodelling

1. Anti-papp-a antibody decreases insulin/IGF-1 signalling in mice.

   “anti-PAPP-A reduced IGF signaling and extracellular matrix (ECM) gene expression system wide.”

   Animals

   Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells

   Aging cell·9 Feb 2021

More on Insulin/IGF-1 signalling