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Anti-isodgr mab

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 2 countries
  • Funders: Barts Charity and 6 more
  • Animals1

Outcomes

4

Cognition/coordination metrics

upin mice1

1 study

  1. Anti-isodgr mab improves cognition/coordination metrics in mice.

    “improved cognition/coordination metrics”

    AnimalsPcmt1-/- mouse1 mg/kg

    Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation

    EMBO molecular medicine16 Nov 2023

Pro-inflammatory cytokines

downin mice1

1 study

  1. Anti-isodgr mab decreases pro-inflammatory cytokines in mice.

    “decreased pro-inflammatory cytokine concentrations in blood plasma”

    AnimalsPcmt1-/- mouseplasma1 mg/kg

    Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation

    EMBO molecular medicine16 Nov 2023

More on Pro-inflammatory cytokines

isoDGR-protein levels

downin mice1

1 study

  1. Anti-isodgr mab decreases isoDGR-protein levels in mice.

    “weekly injection of anti-isoDGR mAb (1 mg/kg) was sufficient to significantly reduce isoDGR-protein levels in body tissues”

    AnimalsPcmt1-/- mouse1 mg/kg

    Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation

    EMBO molecular medicine16 Nov 2023

More on isoDGR-protein levels

Lifespan

upin mice1

1 study

  1. Anti-isodgr mab extends lifespan in mice.

    “extended the average lifespan of Pcmt1-/- mice”

    AnimalsPcmt1-/- mouse1 mg/kg

    Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation

    EMBO molecular medicine16 Nov 2023

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