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ANTI-IL-6 antibody

Intervention

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 3 independent labs in 3 countries
  • Funders: Agència de Gestió d'Ajuts Universitaris i de Recerca and 3 more
  • Animals2

Outcomes

3

Disease severity

no changein mice1

1 study

  1. ANTI-IL-6 antibody has no effect on disease severity in mice.

    “The blockade of IL-6 signaling did not improve the clinical course of EAE in an aging context.”

    Animalsin aged EAE mice

    IL-6 Inhibition as a Therapeutic Target in Aged Experimental Autoimmune Encephalomyelitis

    International journal of molecular sciencesJun 19, 2024

Cognitive function

upin mice1

1 study

  1. ANTI-IL-6 antibody improves cognitive function in mice.

    “An IL-6 antibody protected cognitive function”

    Animals

    Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6

    MicrobiomeMay 30, 2023

Combined hepatocellular-cholangiocarcinoma

downin mice1

1 study

  1. ANTI-IL-6 antibody prevents combined hepatocellular-cholangiocarcinoma in mice.

    “Administration of an anti-IL-6 antibody to Mdr2-KOFoxl1-CRE;RosaYFP mice inhibited the development of cHCC-CCA tumors.”

    Animalsin Mdr2-KOFoxl1-CRE; RosaYFP miceliver

    Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling

    Journal of hepatologyAug 18, 2022

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