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ANTI-IL-11

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 2 countries
  • Funders: British Heart Foundation and others
  • Animals1

Outcomes

3

Muscle function

upin mice1

1 study

  1. ANTI-IL-11 improves muscle function in mice.

    “Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves metabolism and muscle function, and reduces ageing biomarkers and frailty across sexes.”

    Animals25 weeks

    Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

    Nature17 Jul 2024

Frailty

downin mice1

1 study

  1. ANTI-IL-11 decreases frailty in mice.

    “Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves metabolism and muscle function, and reduces ageing biomarkers and frailty across sexes.”

    Animals25 weeks

    Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

    Nature17 Jul 2024

Lifespan

upin mice1+23%

1 study

  1. ANTI-IL-11 extends lifespan in mice (22.5%).

    “Treatment with anti-IL-11 from 75 weeks of age until death extends the median lifespan of male mice by 22.5%”

    Animalsuntil deathmales

    Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

    Nature17 Jul 2024

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