ANTI-GD3 antibody

2 papers8 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Institut National de la Santé et de la Recherche Médicale and 1 more

Humans1
Animals1

Outcomes

Fibrosis

downin mice1

1 study

ANTI-GD3 antibody decreases fibrosis in mice.
“Anti-GD3 treatment also mitigated fibrosis in lung, liver, and kidney tissues with distinct sex-dependent responses.”
Animalsdistinct sex-dependent responseslung, liver, and kidneyshort-term treatmentmale and females
Targeting the senescence-associated immune checkpoint GD3 ganglioside extends healthspan and blunt age-related diseases with sex-specific benefits
bioRxiv (Cold Spring Harbor Laboratory)7 Jan 2026Preprint

More on Fibrosis

Overall survival

no changein mice1

1 study

ANTI-GD3 antibody has no effect on overall survival in mice.
“in females it reduced cancer-specific mortality without significantly affecting overall survival.”
Animalsshort-term treatmentfemales
Targeting the senescence-associated immune checkpoint GD3 ganglioside extends healthspan and blunt age-related diseases with sex-specific benefits
bioRxiv (Cold Spring Harbor Laboratory)7 Jan 2026Preprint

Cancer-specific mortality

downin mice1

1 study

ANTI-GD3 antibody decreases cancer-specific mortality in mice.
“in females it reduced cancer-specific mortality without significantly affecting overall survival.”
Animalsshort-term treatmentfemales
Targeting the senescence-associated immune checkpoint GD3 ganglioside extends healthspan and blunt age-related diseases with sex-specific benefits
bioRxiv (Cold Spring Harbor Laboratory)7 Jan 2026Preprint

Non-cancer mortality

downin mice1

1 study

ANTI-GD3 antibody decreases non-cancer mortality in mice.
“Treatment improved healthspan, survival (+20%) and reduced non-cancer mortality in males”
Animalsshort-term treatmentmales
Targeting the senescence-associated immune checkpoint GD3 ganglioside extends healthspan and blunt age-related diseases with sex-specific benefits
bioRxiv (Cold Spring Harbor Laboratory)7 Jan 2026Preprint

Survival

upin mice1+20% survival

1 study

ANTI-GD3 antibody increases survival in mice (+20% survival).
“Treatment improved healthspan, survival (+20%) and reduced non-cancer mortality in males”
Animalsshort-term treatmentmales
Targeting the senescence-associated immune checkpoint GD3 ganglioside extends healthspan and blunt age-related diseases with sex-specific benefits
bioRxiv (Cold Spring Harbor Laboratory)7 Jan 2026Preprint

Healthspan

upin mice1

1 study

ANTI-GD3 antibody improves healthspan in mice.
“Treatment improved healthspan, survival (+20%) and reduced non-cancer mortality in males”
Animalsshort-term treatmentmales
Targeting the senescence-associated immune checkpoint GD3 ganglioside extends healthspan and blunt age-related diseases with sex-specific benefits
bioRxiv (Cold Spring Harbor Laboratory)7 Jan 2026Preprint

Subchondral bone remodeling

downin mice1

1 study

ANTI-GD3 antibody protects against subchondral bone remodeling in mice.
“reduced local expression of senescence and OA markers in association with a protection against OA-induced subchondral bone remodeling.”
Animalsin experimental OA modelintra-articular delivery
The ganglioside GD3 and its synthase (ST8SIA1) as novel senescence markers associated with osteoarthritis
GeroScience16 Oct 2025

Cellular senescence

downin mice1

1 study

ANTI-GD3 antibody inhibits cellular senescence in mice.
“Intra-articular anti-GD3 antibody delivery in experimental OA model reduced local expression of senescence and OA markers”
Animalsin experimental OA modelintra-articular delivery
The ganglioside GD3 and its synthase (ST8SIA1) as novel senescence markers associated with osteoarthritis
GeroScience16 Oct 2025