Androstenedione

2 papers2 findings

PubChem ChEBI MeSH

2 independent labs in 1 country

Funders: Arizona Department of Health Services and 6 more

Humans1
Animals1

Outcomes

1

Spatial memory

downin rats1

1 study

Androstenedione impairs spatial memory in rats.
“Here, androstenedione administration impaired spatial reference and working memory.”
Animalsin young adult ovariectomized ratsfemales
Pharmacological blockade of the aromatase enzyme, but not the androgen receptor, reverses androstenedione-induced cognitive impairments in young surgically menopausal rats
Steroids23 Aug 2014

Associations

1

Cardiovascular events

downin humans1OR 0.69

1 study

Androstenedione lowers the risk of cardiovascular events in humans (OR 0.69, 95% CI 0.48–1.00).
“For androstenedione, a modest inverse association was observed in females at Q2 (OR 0.69; 95% CI: 0.48–1.00; P < 0.05)”
HumansQ2 vs Q1females
Circulating Androgen Precursors and Cardiovascular Risk: Insights From NHANES 2017-2023
AHA Scientific Sessions 2025 abstract3 Nov 2025

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