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AM3 + antioxidants

AM3 + antioxidants has been studied in 1 paper since 2023: 1 trial in people. The newest paper, Dec 8, 2023: “Immunomodulation with AM3 and antioxidants creates an adequate framework for skin repair and decreases the monocyte proinflammatory stage in smoker women”.

Intervention

1 paper studies it5 findingsUpdated

“AM3 plus antioxidants treatment compared with placebo significantly reduced the monocyte production of the proinflammatory interleukin 1 (IL-1), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) cytokines”
Immunomodulation with AM3 and antioxidants creates an adequate framework for skin repair and decreases the monocyte proinflammatory stage in smoker womenBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2023doi:10.1016/j.biopha.2023.115929

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: European Research Council
  • 5 of 5 findings with company ties
  • Human trial1

What did studies of AM3 + antioxidants find?

5

Studies of AM3 + antioxidants measured 5 outcomes; the most studied are phagocytic activity (1 study), oxidative stress and ROS signaling (1) and reticular dermis depth (1).

Phagocytic activity

upin humans1

1 study

  1. AM3 + antioxidants increase phagocytic activity in humans.

    “increased their phagocytic activity”

    Human trialhealthy smoker womenthree monthsfemalesn = 32

    Immunomodulation with AM3 and antioxidants creates an adequate framework for skin repair and decreases the monocyte proinflammatory stage in smoker women

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Oxidative stress and ROS signaling

no changein humans1

1 study

  1. AM3 + antioxidants have no effect on oxidative stress and ROS signaling in humans.

    “AM3 and antioxidants did not modify ROS production by monocytes and granulocytes”

    Human trialhealthy smoker womenthree monthsfemalesn = 32

    Immunomodulation with AM3 and antioxidants creates an adequate framework for skin repair and decreases the monocyte proinflammatory stage in smoker women

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

More on Oxidative stress and ROS signaling

Reticular dermis depth

upin humans1

1 study

  1. AM3 + antioxidants increase reticular dermis depth in humans.

    “The active combination also stimulated a significative increase in reticular dermis depth”

    Human trialhealthy smoker womenskinthree monthsfemalesn = 32

    Immunomodulation with AM3 and antioxidants creates an adequate framework for skin repair and decreases the monocyte proinflammatory stage in smoker women

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

More on Reticular dermis depth

IL-10

upin humans1

1 study

  1. AM3 + antioxidants increase IL-10 in humans.

    “as well as increased the regulatory IL-10 in middle-aged smoker women”

    Human trialhealthy smoker womenthree monthsfemalesn = 32

    Immunomodulation with AM3 and antioxidants creates an adequate framework for skin repair and decreases the monocyte proinflammatory stage in smoker women

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

More on IL-10

Inflammation

downin humans1

1 study

  1. AM3 + antioxidants decrease inflammation in humans.

    “AM3 plus antioxidants treatment compared with placebo significantly reduced the monocyte production of the proinflammatory interleukin 1 (IL-1), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) cytokines”

    Human trialhealthy smoker womenthree monthsfemalesn = 32

    Immunomodulation with AM3 and antioxidants creates an adequate framework for skin repair and decreases the monocyte proinflammatory stage in smoker women

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

More on Inflammation

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