Alpha-mangostin

1. Alpha-mangostin extends lifespan in worms.

   “The loss of lifespan induced by 6-OHDA in the N2 strain was fully reversed by high concentrations of α-Man.”

   Model organismsin 6-OHDA-exposed N2 nematodes

   Alpha-Mangostin Alleviates the Short-term 6-Hydroxydopamine-Induced Neurotoxicity and Oxidative Damage in Rat Cortical Slices and in Caenorhabditis elegans

   Neurotoxicity research·5 Apr 2022

2. Alpha-mangostin protects against lifespan in worms.

   “In wild-type (N2) C. elegans, α-Man (5-100 μM) protected against 6-OHDA (25 mM)-induced decrease in survival when administered either as pre- or post-treatment.”

   Model organismsin 6-OHDA-exposed N2 nematodes5-100 μM

   Alpha-Mangostin Alleviates the Short-term 6-Hydroxydopamine-Induced Neurotoxicity and Oxidative Damage in Rat Cortical Slices and in Caenorhabditis elegans

   Neurotoxicity research·5 Apr 2022

1. Alpha-mangostin decreases malondialdehyde in chickens.

   “Serum and hepatic antioxidant capacities were significantly enhanced, with increased glutathione peroxidase and catalase activities, elevated total antioxidant capacity, and decreased malondialdehyde levels (p < 0.05).”

   Animals120 mg/kg4 weeksfemalesn = 576

   Effects of Dietary Supplementation with α-Mangostin on Oviduct Inflammation and Eggshell Quality in Aging Laying Hens

   Animals : an open access journal from MDPI·5 Apr 2026

More on Malondialdehyde

1. Alpha-mangostin decreases feed-to-egg ratio in chickens.

   “Dietary supplementation with α-mangostin, particularly at 120 mg/kg, significantly improved feed efficiency (p < 0.05), as evidenced by a reduced feed-to-egg ratio from week 2 onward”

   Animals120 mg/kg4 weeksfemalesn = 576

   Effects of Dietary Supplementation with α-Mangostin on Oviduct Inflammation and Eggshell Quality in Aging Laying Hens

   Animals : an open access journal from MDPI·5 Apr 2026

1. Alpha-mangostin decreases interleukin-1β in chickens.

   “Moreover, α-Ma at 120 mg/kg specifically lowered the concentration of the pro-inflammatory cytokine interleukin-1β in both serum and uterine tissue (p < 0.05).”

   Animalsuterus120 mg/kg4 weeksfemalesn = 576

   Effects of Dietary Supplementation with α-Mangostin on Oviduct Inflammation and Eggshell Quality in Aging Laying Hens

   Animals : an open access journal from MDPI·5 Apr 2026

More on Interleukin-1β

1. Alpha-mangostin improves eggshell strength in chickens.

   “After 4 weeks, hens receiving 120 mg/kg α-Ma exhibited significantly greater egg weight and eggshell strength (p < 0.05).”

   Animals120 mg/kg4 weeksfemalesn = 576

   Effects of Dietary Supplementation with α-Mangostin on Oviduct Inflammation and Eggshell Quality in Aging Laying Hens

   Animals : an open access journal from MDPI·5 Apr 2026

1. Alpha-mangostin prevents neurodegeneration in worms.

   “α-Man (25 μM) also prevented 6-OHDA-induced dopaminergic neurodegeneration in the BZ555 C. elegans strain.”

   Model organismsin 6-OHDA-exposed BZ555 nematodes25 μM

   Alpha-Mangostin Alleviates the Short-term 6-Hydroxydopamine-Induced Neurotoxicity and Oxidative Damage in Rat Cortical Slices and in Caenorhabditis elegans

   Neurotoxicity research·5 Apr 2022

1. Alpha-mangostin decreases lipid peroxidation in rats.

   “In rat cortical slices, α-Man (25 and 50 μM) reduced the 6-OHDA (100 μM)-induced oxidative damage to lipid levels”

   Animalsin rat cortical slices exposed to 6-OHDAcortex25 and 50 μM

   Alpha-Mangostin Alleviates the Short-term 6-Hydroxydopamine-Induced Neurotoxicity and Oxidative Damage in Rat Cortical Slices and in Caenorhabditis elegans

   Neurotoxicity research·5 Apr 2022

More on Lipid peroxidation