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Mag + alnnnd

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Institute of Diabetes and Digestive and Kidney Diseases and 2 more
  • Animals1

Outcomes

4

Basement membrane stability

upin mice1

1 study

  1. Mag + alnnnd improves basement membrane stability in mice.

    “fully restored basement membrane stability”

    Animalstransgenic expression in a mouse model for LAMA2 MD

    Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice

    Science translational medicine28 Jun 2017

Overall body weight

upin mice1

1 study

  1. Mag + alnnnd increases overall body weight in mice.

    “fully restored basement membrane stability, recovered muscle force and size, increased overall body weight”

    Animalstransgenic expression in a mouse model for LAMA2 MD

    Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice

    Science translational medicine28 Jun 2017

Muscle force

upin mice1

1 study

  1. Mag + alnnnd improves muscle force in mice.

    “fully restored basement membrane stability, recovered muscle force and size, increased overall body weight”

    Animalstransgenic expression in a mouse model for LAMA2 MD

    Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice

    Science translational medicine28 Jun 2017

Lifespan

upin mice1

1 study

  1. Mag + alnnnd extends lifespan in mice (>5 times).

    “extended life span more than five times to a maximum survival beyond 2 years”

    Animalstransgenic expression in a mouse model for LAMA2 MD

    Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice

    Science translational medicine28 Jun 2017

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