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Adenosine A2A receptor antagonist

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Li Ka Shing Foundation and 1 more
  • Animals1

Outcomes

1

Motor skill performance

upin mice1

1 study

  1. Adenosine A2A receptor antagonist improves motor skill performance in mice.

    “infusing an A2AR antagonist, in order to offset the disinhibition effect, restores motor skill performance in aged mice”

    Animalsdorsolateral striatum

    Reduced inhibitory synaptic transmission onto striatopallidal neurons may underlie aging-related motor skill deficits

    Neurobiology of disease26 Jun 2024

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