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Adenosine A2A receptor agonist

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Li Ka Shing Foundation and 1 more
  • Animals1

Outcomes

1

Motor skill performance

downin mice1

1 study

  1. Adenosine A2A receptor agonist impairs motor skill performance in mice.

    “an adenosine A2A receptor (A2AR) agonist, which presumably mimics the disinhibition effect, impairs motor skill performance in young mice”

    Animalsdorsolateral striatum

    Reduced inhibitory synaptic transmission onto striatopallidal neurons may underlie aging-related motor skill deficits

    Neurobiology of disease26 Jun 2024

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