ACTA2
upin mice1
Adenine increases ACTA2 in mice (8-fold rise).
“Adenine caused renal fibrosis, as evidenced by collagen deposition and an eight‐fold rise of α‐smooth muscle actin in the kidneys of all the adenine‐fed mice.”
Animalskidney0.2%four weeks
An alternative source of elevated tau phosphorylation in plasma following renal dysfunction
AAIC 2025 abstract25 Dec 2025
Inflammation
upin mice1
Adenine increases inflammation in mice.
“Similarly, microglia became less ramified if adenine was treated with the aged mice.”
Animalsadenine-induced CKDbrain
An alternative source of elevated tau phosphorylation in plasma following renal dysfunction
AAIC 2025 abstract25 Dec 2025
In a 52-week randomised trial, disease rating scores rose by 2.45 points with the supplement compared with a 0.27-point fall with placebo.In a 52-week randomised trial, disease rating scores rose by 2.45 points with the supplement compared with a 0.27-point fall with placebo.