AAV9 scCMV-Kcnn1

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Funder: Yale University
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Phospho-serine 129 α-synuclein

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AAV9 scCMV-Kcnn1 decreases phospho-serine 129 α-synuclein in mice.
“blocking production of phospho-serine 129 α-synuclein was also observed in adult A53T mice injected presymptomatically with an AAV9 scCMV-Kcnn1 virus into the right superior colliculus”
Animalsin adult A53T mice injected presymptomatically into right superior colliculussuperior colliculus~2 mo
Neuronal overexpression of Kcnn1 in A53T α-synuclein mice suppresses phospho-serine 129 α-synuclein formation and doubles survival time
Proceedings of the National Academy of Sciences of the United States of America19 Aug 2026

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PNAS19 Aug

Neuronal overexpression of Kcnn1 in A53T α-synuclein mice suppresses phospho-serine 129 α-synuclein formation and doubles survival time

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