Phospho-serine 129 α-synuclein

1. AAV9 scCMV-Kcnn1 decreases phospho-serine 129 α-synuclein in mice.

   “blocking production of phospho-serine 129 α-synuclein was also observed in adult A53T mice injected presymptomatically with an AAV9 scCMV-Kcnn1 virus into the right superior colliculus”

   Animalsin adult A53T mice injected presymptomatically into right superior colliculussuperior colliculus~2 mo

   Neuronal overexpression of Kcnn1 in A53T α-synuclein mice suppresses phospho-serine 129 α-synuclein formation and doubles survival time

   Proceedings of the National Academy of Sciences of the United States of America·19 Aug 2026

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1. KCNN1 decreases phospho-serine 129 α-synuclein in mice.

   “accretion of disease-associated phospho-serine 129 α-synuclein was prevented by overexpression of Thy1.2-driven Kcnn1 in many brain regions/spinal cord”

   Animalsin Thy1.2-driven human A53T α-synuclein mice

   Neuronal overexpression of Kcnn1 in A53T α-synuclein mice suppresses phospho-serine 129 α-synuclein formation and doubles survival time

   Proceedings of the National Academy of Sciences of the United States of America·19 Aug 2026

More on KCNN1