KCNN1

1. KCNN1 improves dystonic-like behavior in mice (onset delayed to 12 to 16 mo).

   “altered presentation from rapidly progressive dystonic-like behavior of the limbs to a later-onset (12 to 16 mo) and slowly progressive lower limb clasping”

   Animalsin Thy1.2-driven human A53T α-synuclein mice

   Neuronal overexpression of Kcnn1 in A53T α-synuclein mice suppresses phospho-serine 129 α-synuclein formation and doubles survival time

   Proceedings of the National Academy of Sciences of the United States of America·19 Aug 2026

1. KCNN1 decreases phospho-serine 129 α-synuclein in mice.

   “accretion of disease-associated phospho-serine 129 α-synuclein was prevented by overexpression of Thy1.2-driven Kcnn1 in many brain regions/spinal cord”

   Animalsin Thy1.2-driven human A53T α-synuclein mice

   Neuronal overexpression of Kcnn1 in A53T α-synuclein mice suppresses phospho-serine 129 α-synuclein formation and doubles survival time

   Proceedings of the National Academy of Sciences of the United States of America·19 Aug 2026

More on Phospho-serine 129 α-synuclein

1. KCNN1 extends lifespan in mice (from 8.5 to 18 mo).

   “Kcnn1 overexpression increased median survival of these mice from 8.5 to 18 mo”

   Animalsin transgenic Thy1.2-driven human A53T α-synuclein mice

   Neuronal overexpression of Kcnn1 in A53T α-synuclein mice suppresses phospho-serine 129 α-synuclein formation and doubles survival time

   Proceedings of the National Academy of Sciences of the United States of America·19 Aug 2026