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AAV9-NPC1

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: China Postdoctoral Science Foundation and 2 more
  • Animals1

Outcomes

3

Locomotor activity

upin mice1

1 study

  1. AAV9-NPC1 improves locomotor activity in mice.

    “restored locomotor activity and coordination”

    AnimalsNPC1-/- miceAAV9-NPC1one single injection

    AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC disease

    Journal of lipid research4 Jan 2017

Purkinje cell survival

upin mice1

1 study

  1. AAV9-NPC1 improves purkinje cell survival in mice.

    “AAV9-mediated NPC1 delivery significantly promoted Purkinje cell survival”

    AnimalsNPC1-/- miceAAV9-NPC1Purkinje cellone single injection

    AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC disease

    Journal of lipid research4 Jan 2017

Lifespan

upin mice1

1 study

  1. AAV9-NPC1 extends lifespan in mice.

    “increased the lifespan of NPC1-/- mice”

    AnimalsNPC1-/- miceAAV9-NPC1one single injection

    AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC disease

    Journal of lipid research4 Jan 2017

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