AAV2-SKL

1. AAV2-SKL increases Skl in mice.

   “Skl gene delivery effectively increased serum Skl of SAMP1 mice to the control level.”

   Animalsin SAMP1 miceserum

   Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1

   Hypertension (Dallas, Tex. : 1979)·26 Mar 2018

More on Skl

1. AAV2-SKL inhibits inflammation in mice.

   “Skl gene delivery inhibited inflammation and myofibroblastic transition in aortic valves and attenuated fibrotic aortic valve disease in SAMP1 mice.”

   Animalsin SAMP1 miceaortic valve

   Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1

   Hypertension (Dallas, Tex. : 1979)·26 Mar 2018

More on Inflammation

1. AAV2-SKL decreases aortic valve fibrosis in mice.

   “Restoration of serum Skl levels by adeno-associated virus 2 carrying mouse Skl cDNA effectively suppresses inflammation and myofibroblastic transition and attenuates aortic valve fibrosis.”

   Animalsin SAMP1 miceaortic valve

   Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1

   Hypertension (Dallas, Tex. : 1979)·26 Mar 2018

More on Aortic valve fibrosis