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Aav-mediated restoration of core 1 mucin-type o-glycans

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 2 more
  • Animals1

Outcomes

3

Cognitive deficits

downin mice1

1 study

  1. Aav-mediated restoration of core 1 mucin-type o-glycans decrease cognitive deficits in mice.

    “reduce neuroinflammation and cognitive deficits in aged mice by restoring core 1 mucin-type O-glycans to the brain endothelium using adeno-associated viruses”

    Animalsbrain endothelium

    Glycocalyx dysregulation impairs blood-brain barrier in ageing and disease

    Nature26 Feb 2025

Inflammation

downin mice1

1 study

  1. Aav-mediated restoration of core 1 mucin-type o-glycans decrease inflammation in mice.

    “reduce neuroinflammation and cognitive deficits in aged mice by restoring core 1 mucin-type O-glycans to the brain endothelium using adeno-associated viruses”

    Animalsbrain endothelium

    Glycocalyx dysregulation impairs blood-brain barrier in ageing and disease

    Nature26 Feb 2025

More on Inflammation

Blood-brain barrier integrity

upin mice1

1 study

  1. Aav-mediated restoration of core 1 mucin-type o-glycans improve blood-brain barrier integrity in mice.

    “improve BBB function and reduce neuroinflammation and cognitive deficits in aged mice by restoring core 1 mucin-type O-glycans to the brain endothelium using adeno-associated viruses”

    Animalsbrain endothelium

    Glycocalyx dysregulation impairs blood-brain barrier in ageing and disease

    Nature26 Feb 2025

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