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AAV-CDKN2A-OSK

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 2 countries
  • 3 of 3 findings with company ties
  • Animals1

Outcomes

3

Proinflammatory cytokines

downin mice1

1 study

  1. AAV-CDKN2A-OSK decreases proinflammatory cytokines in mice.

    “Mice showed reduced expression of proinflammatory cytokines and extended life spans upon aged cell-specific OSK expression”

    Animalsin a mouse model of Hutchinson-Gilford progeria syndrome (HGPS)

    Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging

    Science translational medicine11 Sep 2024

More on Proinflammatory cytokines

Wound healing

upin mice1

1 study

  1. AAV-CDKN2A-OSK improves wound healing in mice.

    “intradermal injection of AAVs carrying Cdkn2a-OSK led to improved wound healing in aged wild-type mice”

    Animalsin aged wild-type miceintradermal injection

    Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging

    Science translational medicine11 Sep 2024

Lifespan

upin mice1

1 study

  1. AAV-CDKN2A-OSK extends lifespan in mice.

    “extended life spans upon aged cell-specific OSK expression”

    Animalsin a mouse model of Hutchinson-Gilford progeria syndrome (HGPS)

    Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging

    Science translational medicine11 Sep 2024

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