8-oxo-guanine
1 paper studies it3 findings
- 1 lab in 1 country
- Funders: National Cancer Institute and 4 more
- Cells1
Outcomes
3Telomeric fragile sites
upin human cells1
1 study
Telomeric fragile sites
upin human cells1
8-oxo-guanine increases telomeric fragile sites in human cells.
“generates fragile sites and mitotic DNA synthesis at telomeres, indicative of impaired replication.”
Cellsin replicating cells
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening
Nature structural & molecular biologyJun 30, 2022
Telomere length
no changein human cells1
1 study
Telomere length
no changein human cells1
8-oxo-guanine has no effect on telomere length in human cells.
“Acute 8oxoG production fails to shorten telomeres”
Cellsin human fibroblasts and epithelial cells
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening
Nature structural & molecular biologyJun 30, 2022
Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
8-oxo-guanine induces cellular senescence in human cells.
“A single induction of telomeric 8oxoG is sufficient to trigger multiple hallmarks of p53-dependent senescence.”
Cellsin human fibroblasts and epithelial cells
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening
Nature structural & molecular biologyJun 30, 2022