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7-amino-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ol

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Cells1

Outcomes

4

mTOR signalling

upin human cells1

1 study

  1. 7-amino-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ol activates mTOR signalling in human cells.

    “We found that ABO decreased AMPK phosphorylation and increased the phosphorylation level and activity of mTOR.”

    Cellsdermis

    Inhibition of annexin A7 suppresses senescence-associated heterochromatin foci formation and senescence through the AMPK/mTOR pathway in human dermal fibroblasts

    Journal of cellular biochemistrySep 8, 2023

More on mTOR signalling

AMPK signalling

downin human cells1

1 study

  1. 7-amino-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ol inhibits AMPK signalling in human cells.

    “We found that ABO decreased AMPK phosphorylation and increased the phosphorylation level and activity of mTOR.”

    Cellsdermis

    Inhibition of annexin A7 suppresses senescence-associated heterochromatin foci formation and senescence through the AMPK/mTOR pathway in human dermal fibroblasts

    Journal of cellular biochemistrySep 8, 2023

More on AMPK signalling

Cellular senescence

downin human cells1

1 study

  1. 7-amino-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ol inhibits cellular senescence in human cells.

    “As a result, ABO inhibited the senescence of human dermal fibroblasts (HDFs).”

    Cellsdermis

    Inhibition of annexin A7 suppresses senescence-associated heterochromatin foci formation and senescence through the AMPK/mTOR pathway in human dermal fibroblasts

    Journal of cellular biochemistrySep 8, 2023

More on Cellular senescence

Chromatin and 3D genome organisation

downin human cells1

1 study

  1. 7-amino-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ol inhibits chromatin and 3D genome organisation in human cells.

    “found 7-amino-2,3,4,5-tetrahedrobenzo[b][1,4] oxazepin-3-ol (ABO) that was identified as an inhibitor of annexin A7 GTPase (ANXA7) dramatically suppressed the aggregation of heterochromatin protein (HP1γ)”

    Cellsdermis

    Inhibition of annexin A7 suppresses senescence-associated heterochromatin foci formation and senescence through the AMPK/mTOR pathway in human dermal fibroblasts

    Journal of cellular biochemistrySep 8, 2023

More on Chromatin and 3D genome organisation

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