3-nitropropionic acid
3-nitropropionic acid has been studied in 1 paper since 2017: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Aug 18, 2017: “Comparison of the Toxic Effects of Quinolinic Acid and 3-Nitropropionic Acid in C. elegans: Involvement of the SKN-1 Pathway”.
See all 13 papers on 3-nitropropionic acid
At a glance
The findings reach mice, none yet in people. 2 independent labs in 2 countries.
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: DOST and 1 more
- Model organisms1
What did studies of 3-nitropropionic acid find?
6Studies of 3-nitropropionic acid measured 6 outcomes; the most studied are lifespan (1 study), survival (1) and oxidative damage (1).
Lifespan
downin worms1
1 study
Lifespan
downin worms1
3-nitropropionic acid shortens lifespan in VC1772 strain (skn-1 knockout) compared to N2.
“Both toxins also reduced longevity in the VC1772 strain (as compared to N2 strain)”
Model organismsin VC1772 strain (skn-1 knockout) compared to N2
Neurotoxicity research
Survival
downin worms1
1 study
Survival
downin worms1
3-nitropropionic acid decreases survival in worms (higher doses).
“In N2, the higher doses of both toxins decreased survival”
Model organismshigher doseshigh doses
Neurotoxicity research
Oxidative damage
upin mice1
1 study
Oxidative damage
upin mice1
3-nitropropionic acid induces oxidative damage in young and adult mice.
“3-NPA injection in vivo caused motor impairment, mitochondrial dysfunction and oxidative damage with different trend in young and adult mice.”
Animalsin young and adult miceinjection
Mechanisms of ageing and development
Motor function
downin mice1
1 study
Motor function
downin mice1
3-nitropropionic acid impairs motor function in young and adult mice.
“3-NPA injection in vivo caused motor impairment, mitochondrial dysfunction and oxidative damage with different trend in young and adult mice.”
Animalsin young and adult miceinjection
Mechanisms of ageing and development
Oxidative stress and ROS signaling
upin mouse cells1
1 study
Oxidative stress and ROS signaling
upin mouse cells1
3-nitropropionic acid induces oxidative stress and ROS signaling in mouse cells (neuronal cells).
“3-NPA induced neuronal death, oxidative stress and altered mitochondrial structure in neuronal cells.”
Cellsneuronal cells
Mechanisms of ageing and development
Neuronal death
upin mouse cells1
1 study
Neuronal death
upin mouse cells1
3-nitropropionic acid induces neuronal death in mouse cells (neuronal cells).
“3-NPA induced neuronal death, oxidative stress and altered mitochondrial structure in neuronal cells.”
Cellsneuronal cells
Mechanisms of ageing and development