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3-bromopyruvate

3-bromopyruvate has been studied in 1 paper since 2022: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Apr 5, 2022: “Hormetic Effect of 3-Bromopyruvate on Age-Induced Alterations in Erythrocyte Membrane Transporters and Oxidative Biomarkers in Rats”.

Intervention

1 paper studies it3 more mention it5 findingsUpdated

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Animals1

What did studies of 3-bromopyruvate find?

5

Studies of 3-bromopyruvate measured 5 outcomes; the most studied are osmotic fragility (1 study), oxidative stress and ROS signaling (1) and Na+/H+ exchanger (1).

Osmotic fragility

downin rats1

1 study

  1. 3-bromopyruvate decreases osmotic fragility in rats.

    “It also exerts a concomitant decrease in Na+/H+ exchanger (NHE) activity and the levels of [Ca2+]i, PC, and osmotic fragility in aged groups.”

    Animalschronic low doseerythrocyte4 weeksmales

    Hormetic Effect of 3-Bromopyruvate on Age-Induced Alterations in Erythrocyte Membrane Transporters and Oxidative Biomarkers in Rats

    Rejuvenation research

Oxidative stress and ROS signaling

downin rats1

1 study

  1. 3-bromopyruvate decreases oxidative stress and ROS signaling in rats.

    “It also exerts a concomitant decrease in Na+/H+ exchanger (NHE) activity and the levels of [Ca2+]i, PC, and osmotic fragility in aged groups.”

    Animalschronic low doseerythrocyte4 weeksmales

    Hormetic Effect of 3-Bromopyruvate on Age-Induced Alterations in Erythrocyte Membrane Transporters and Oxidative Biomarkers in Rats

    Rejuvenation research

More on Oxidative stress and ROS signaling

Na+/H+ exchanger

downin rats1

1 study

  1. 3-bromopyruvate decreases Na+/H+ exchanger in rats.

    “It also exerts a concomitant decrease in Na+/H+ exchanger (NHE) activity and the levels of [Ca2+]i, PC, and osmotic fragility in aged groups.”

    Animalschronic low doseerythrocyte membrane4 weeksmales

    Hormetic Effect of 3-Bromopyruvate on Age-Induced Alterations in Erythrocyte Membrane Transporters and Oxidative Biomarkers in Rats

    Rejuvenation research

Ca2+-ATPase

upin rats1

1 study

  1. 3-bromopyruvate increases Ca2+-ATPase in rats.

    “In aged rats, 3-BP treatment increases the membrane-bound activities of Na+/K+-ATPase (NKA) and Ca2+-ATPase (PMCA), along with levels of -SH and SA.”

    Animalschronic low doseerythrocyte membrane4 weeksmales

    Hormetic Effect of 3-Bromopyruvate on Age-Induced Alterations in Erythrocyte Membrane Transporters and Oxidative Biomarkers in Rats

    Rejuvenation research

Na+/K+-ATPase

upin rats1

1 study

  1. 3-bromopyruvate increases Na+/K+-ATPase in rats.

    “In aged rats, 3-BP treatment increases the membrane-bound activities of Na+/K+-ATPase (NKA) and Ca2+-ATPase (PMCA), along with levels of -SH and SA.”

    Animalschronic low doseerythrocyte membrane4 weeksmales

    Hormetic Effect of 3-Bromopyruvate on Age-Induced Alterations in Erythrocyte Membrane Transporters and Oxidative Biomarkers in Rats

    Rejuvenation research

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